Publications

2024

Insights from structure-activity relationships and the binding mode of peptidic α-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1

Legru A., Batista F.A., Puszko A.K., Bouillon A., Maurel M., Martinez M., Ejjoummany A., Ortega Varga L., Adler P., Mechaly A., Hadjadj M., Sosnowski P., Hopfgartner G., Alzari P.M., Blondel A., Haouz A., Barale J.-Ch.*, Hernandez J.-F.*

Eur J Med Chem (2024) 269,116308

DOI: 10.1016/j.ejmech.2024.116308​​

2023

Structure-activity relationship studies and biological properties evaluation of peptidic NRP-1 ligands: Investigation of N-terminal cysteine importance

Puszko A.K.*, Sosnowski P., Hermine O., Hopfgartner G., Lepelletier Y., Misicka A.*

Bioorg Med Chem (2023) 94,117482

DOI: ​10.1016/j.bmc.2023.117482

2022

Oligourea molecular lifter triggered by electric field

Dziubak D., Puszko A.K., Bachurska P., Pułka-Ziach K.*, Sek S.*

Electrochim Acta (2022) 403, 139634

DOI: 10.1016/j.electacta.2021.139634

​

2021

Urea-Peptide Hybrids as VEGF-A165/NRP-1 Complex Inhibitors with Improved Receptor Affinity and Biological Properties

Puszko A.K.*, Sosnowski P., Rignault-Bricard R., Hermine O., Hopfgartner G., Pułka-Ziach K., Lepelletier Y., Misicka A.*

Int J Mol Sci (2021) 22, 72

DOI: 10.3390/ijms22010072

​

Neuropilin 1 and Neuropilin 2 gene invalidation or pharmacological inhibition reveals their relevance for the treatment of metastatic renal cell carcinoma

Dumond A., Brachet E., Durivault J., Vial V., Puszko A.K., Lepelletier Y., Montemagno Ch., Pagnuzzi-Boncompagni M., Hermine O., Garbay Ch., Lagarde N, Montes M., Demange L., Grépin R., Pagès G.*

J Exp Clin Cancer Res (2021) 40, 33

DOI: 10.1186/s13046-021-01832-x

​

2020

Does Cysteine Rule (CysR) Complete the CendR Principle? Increase in Affinity of Peptide Ligands for NRP-1 Through the Presence of N-Terminal Cysteine

Puszko A.K., Sosnowski P., Raynaud F., Hermine O., Hopfgartner G.,Lepelletier Y.*, Misicka A.*

Biomolecules (2020) 10, e:448

DOI: 10.3390/biom10030448

​

2019

Urea moiety as amide bond mimetic in peptide-like inhibitors of VEGF-A165/NRP-1 complex

Puszko A.K.*, Sosnowski P., Pułka-Ziach K., Hermine O., Hopfgartner G.,Lepelletier Y., Misicka A.*

Bioorg Med Chem Lett (2019) 29, 2493-97

DOI: 10.1016/j.bmcl.2019.07.016

​

Triazolopeptides inhibiting the interaction between Neuropilin-1 and Vascular Endothelial Growth Factor-165

Fedorczyk B., Lipiński P.F.J., Puszko A.K., Tymecka D., Wileńska B., Dudka W., Perret G.Y., Wieczorek R., Misicka A.*

Molecules (2019) 24, 1756

DOI: 10.3390/molecules24091756

​

Neuropilin-1 peptide-like ligands with proline mimetics, tested using the improved chemiluminescence affinity detection method

Puszko A.K.*, Sosnowski P., Tymecka D., Raynaud F., Hermine O., Lepelletier Y., Misicka A.*

MedChemComm (2019) 10, 332-40

DOI: 10.1039/C8MD00537K

​

Electron Transport and a Rectifying Effect of Oligourea Foldamer Films Entrapped within Nanoscale Junctions

Pulka-Ziach K.*, Puszko A.K., Juhaniewicz-Debinska J., Sek S.*

J Phys Chem C (2019) 123, 1136-41

DOI: 10.1021/acs.jpcc.8b11046

2018

Branched pentapeptides as potent inhibitors of the vascular endothelial growth factor 165 binding to Neuropilin-1: Design, synthesis and biological activity

Tymecka D., Puszko A.K., Lipinski P.F.J., Fedorczyk B., Wilenska B., Sura K., Perret G.Y., Misicka A.*

Eur J Med Chem (2018) 158, 453-62

DOI: 10.1016/j.ejmech.2018.08.083

2017

Opioid Tripeptides Hybridized with trans-1-Cinnamylpiperazine as Proliferation Inhibitors of Pancreatic Cancer Cells in Two- and Three-Dimensional in vitro Models

Laskowska A., Puszko A.K., Sosnowski P., Rozycki K., Kosson P., Matalinska J., Durlik M., Misicka A.*

ChemMedChem (2017) 12, 1637-44

DOI: 10.1002/cmdc.201700453

​

The effect of wool hydrolysates on squamous cell carcinoma cells in vitro. Possible implications for cancer treatment

Damps T.*, Laskowska A., Kowalkowski T., Prokopowicz M., Puszko A.K., Sosnowski P., Czuwara J., Konop M., Rozycki K., Borkowska J.K., Misicka A., Rudnicka L.

PLOS ONE (2017) 12, e0184034

DOI: 10.1371/journal.pone.0184034

​

Structure-activity relationship study of tetrapeptide inhibitors of the Vascular Endothelial Growth Factor A binding to Neuropilin-1

Tymecka D., Lipinski P.F.J., Fedorczyk B., Puszko A.K., Wilenska B., Perret G.Y., Misicka A.*

Peptides (2017) 94, 25-32

DOI: 10.1016/j.peptides.2017.06.003

​

Conformational latitude - activity relationship of KPPR tetrapeptide analogues toward their ability to inhibit binding of vascular endothelial growth factor 165 to neuropilin-1

Fedorczyk B., Lipinski P.F.J., Tymecka D., Puszko A.K., Wilenska B., Perret G.Y., Misicka A.*

J Pep Sci (2017) 23, 445-54

DOI: 10.1002/psc.3009

​

Physicochemical properties and in vitro cytotoxicity of iron oxide-based nanoparticles modified with antiangiogenic and antitumor peptide A7R

Niescioruk A., Nieciecka D., Puszko A.K., Krolikowska A., Kosson P., Perret G.Y., Krysinski P., Misicka A.*

J Nanoparticle Res (2017) 19, 160

DOI: 10.1007/s11051-017-3859-x

​

Structure-activity relationship study of a small cyclic peptide H-c[Lys-Pro-Glu]-Arg-OH: a potent inhibitor of Vascular Endothelial Growth Factor interaction with Neuropilin-1

Grabowska K., Puszko A.K., Lipinski P.F.J., Laskowska A., Wilenska B., Witkowska E., Perret G.Y., Misicka A.*

Bioorg Med Chem (2017) 25, ‏ 597-602

DOI: 10.1016/j.bmc.2016.11.024

​

Vasopressin and Related Peptides; Potential Value in Diagnosis, Prognosis and Treatment of Clinical Disorders

Szczepanska-Sadowska E.*, Zera T., Sosnowski P., Cudnoch-Jedrzejewska A., Puszko A.K., Misicka A.

Curr Drug Metab (2017) 18, ‏306-345

DOI: 10.2174/1389200218666170119145900

2016

Design, synthesis and in vitro biological evaluation of a small cyclic peptide as inhibitor of vascular endothelial growth factor binding to neuropilin-1

Grabowska K., Puszko A.K., Lipinski P.F.J., Laskowska A., Wilenska B., Witkowska E., Misicka A.*

Bioorganic Med Chem Lett (2016) 26, 2843-46

DOI: 10.1016/j.bmcl.2016.04.059

2015

Peptides and peptidoaldehydes as substrates for the Pictet-Spengler reaction

Pulka K.*, Slupska M., Puszko A., Misiak M., Wilczek M., Kozminski W., Misicka A.*

J Pep Sci (2015) 19, 433-40

DOI: 10.1002/psc.2516

​